| Pair Name | Cucurbitacin B, Erastin | ||
| Phytochemical Name | Cucurbitacin B (PubChem CID: 5281316 ) | ||
| Anticancer drug Name | Erastin (PubChem CID: 11214940 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cucurbitacin B, Erastin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Ferroptosis | |||
| Gene Regulation | Up-regulation | Expression | IREB2 | hsa3658 |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation | |||
| No. | Title | Href |
|---|---|---|
| 1 | Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation. Toxicol In Vitro. 2024 Feb;94:105732. doi: 10.1016/j.tiv.2023.105732. | Click |
